In order to study the rate of generation of uric acid in man, Benedict, Roche, Yu, Bien, Gutman, and Stetten (5-7) administered relatively large doses of glycine-N15 orally to control and gouty subjects and measured the appearance of isotope in urinary uric acid. With this technique, they demonstrated overincorporation of isotope into uric acid only in gouty subjects excreting large quantities of uric acid in urine. Subsequently, however, excessive incorporation of tracer quantities of glycine-1-C14 into uric acid was demonstrated in all of seven subjects studied, regard-