Article InfoEpilepsy is a group of neurological diseases characterized by epileptic seizures. Levetiracetam is increasingly used as adjunctive anticonvulsant therapy. Levetiracetam is second generation anti epileptic drug. The present review is aimed on the estimation of serum total bilirubin level and hyponatremic effect associated with the use of levetiracetam therapy in epileptic patients. The clinical monitoring of the serum sodium levels is done to identify the development of hyponatremia associated with the use of levetiracetam. Asymptomatic elevation in serum total bilirubin is found in patients taking levetiracetam. The review provides clinical information about the incidence of hyponatremia and serum total bilirubin level associated with levetiracetam therapy.