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Tongue squamous cell carcinoma (TSCC) is the most common head and neck cancer and accounts for 1%-2% of all human malignancies (Erickson, 2017). Many studies have indicated that tobacco smoking is an important risk factor for TSCC (Hashibe et al., 2009). Smoking is related to a poor prognosis in TSCC patients by decreasing survival rate and increasing the risk of recurrence, as well by increasing the incidence of secondary cancers (Warren, Kasza, Reid, Cummings, & Marshall, 2013). Smoking during cancer treatment is associated with

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