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A sensor for biomedical markers based on a split ring microwave resonator (SRR) was developed. The surface of the microwave resonator is covered with receptors that specifically bind to the target proteins where the local permittivity is changed. The resonator is part of a microwave oscillator circuit. Changes in the local permittivity caused by coupling of the target proteins result in a change of oscillator frequency which can be easily and accurate measured with high sensitivity.