We report a case of Staphylococcus lugdunensis bacteraemia following infection of a fragmented totally implantable vascular access device. This report highlights the virulence of S. lugdunensis especially in immunosuppressed patients with prosthetic devices as well as the importance of distinguishing between contamination and blood stream infection when this organism is cultured from blood. The importance of prompt removal of implantable vascular access devices when they are no longer required, to prevent catheter related infections is also reflected in this report. J Microbiol Infect Dis 2015;5(2): 85-88