Graphical Abstract Highlights d Extracellular vesicles (EVs) shed by glioma cells are taken up by microglia in vivo d miR-21 is functionally transferred from glioma to microglia through EVs in vivo d miR-21 mRNA targets in microglia are downregulated upon EV uptake d Microglia proliferation is increased after miR-21 target Btg2 downregulation
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