a 1 8 2 8 c o A G u L A T I o N (PIC). Marc perlman, J e f f r e y cooper, and A s r a r Malik (spon. Bernard P o l l a r a ) . Albany Medical C o l l e g e , Depts. o f P e d i a t r i c s and Physiology, Albany, N.Y.We compared t h e e f f e c t s of cyclooxygenase i n h i b i t o r s , meclofenamate (MEC) and i b u p r o f e n (IBU) on t h e development o f l u n g m c i r o v a s c u l a r i n j u r y a f t e r PIC induced by i . v . thrombin (T) i nf u s i o n (80 U/kg). S t u d i e s were made i n awake (n=10) sheep w i t h l u n g lymph f i s t u l a s . The animals were p r e t r e a t e d w i t h e i t h e r MEC o r IBU. Lung lymph flow (Qlym) lymph-to-plasma p r o t e i n c o n c e n t r a t i o n r a t i o (LIP), and t r a n s v a s c u l a r p r o t e i n c l e a r a n c e (LIP x Qlym) were determined. MEC and IBU p r e v e n t e d t h e in: c r e a s e s i n t h e cyclooxygeanse end-products, thromboxane and 6-keto-PGF1 a f t e r T. T r e s u l t e d i n h-fold i n c r e a s e s i n Qlym and p r o t e i n a c l e a r a n c e , i n d i c a t i n g l u v g m i c r o v a s c u l a r i n j u r y . MEC a t t e n u a t e d t h e i n i t i a l r i s e s i n Qlym and p r o t e i n c l e a r a n c e a f t e r T, w h i l e IBU p r e v e n t e d b o t h i n i t i a l and s t e a d y -s t a t e r es p o n s e s . IBU b u t n o t MEC reduced t h e i n c r e a s e s i n pulmonary a r t e r i a l p r e s s u r e and PVR a f t e r T. I n a n o t h e r group ( n = l l ) ,
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