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Objective The predominant vacA genotype among Filipino patients has yet to be determined. This study aims to determine these common vacA genotypes via Polymerase Chain Reaction detectin using specific primers for each possible genotypes. Materials and methods DNA was obtained from 48 paraffin embedded gastrointestinal tissues from 31 patients of St. Lukeîs Medical Center from 1998 to 1999. Twenty‐three (23) patients were diagnosed with chronic active gastritis; 5 with chronic gastritis; one with chronic ulcer; and 2 with gasto‐intestinal cancer. Results From the PCR results, the signal sequence allele having the highest number among the samples was s1b (35%) while m2 was the common midregion type (42%). Among 12 samples completely genotypes, s1bm2 was most prevalent (50%). One samples from a cancer patient had multiple genotypes (s1am1, s1am2,s1bm1, s1bm2) Conclusion The vacA genotypes s1bm2 is the common genotype detected among the gastric biopsy samples obtained from Filipino patients.