(2010) Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia, Autophagy,6:6,[738][739][740][741][742][743][744][745][746][747][748][749][750][751][752][753]

No abstract

A novel POSS‐containing methacrylate monomer (HEMAPOSS) was fabricated by extending the side chain between polyhedral oligomeric silsesquioxane (POSS) unit and methacrylate group, which can efficiently decrease the steric hindrance in free‐radical polymerization of POSS‐methacrylate monomer. POSS‐containing homopolymers (PHEMAPOSS) with a higher degree of polymerization (DP) can be prepared using HEMAPOSS monomer via reversible addition–fragmentation chain transfer (RAFT) polymerization. PHEMAPOSS was further used as the macro‐RAFT agent to construct a series of amphiphilic POSS‐containing poly(N, N‐dimethylaminoethyl methacrylate) diblock copolymers, PHEMAPOSS‐b‐PDMAEMA. PHEMAPOSS‐b‐PDMAEMA block copolymers can self‐assemble into a plethora of morphologies ranging from irregular assembled aggregates to core‐shell spheres and further from complex spheres (pearl‐necklace‐liked structure) to large compound vesicles. The thermo‐ and pH‐responsive behaviors of the micelles were also investigated by dynamic laser scattering, UV spectroscopy, SEM, and TEM. The results reveal the reversible transition of the assembled morphologies from spherical micelles to complex micelles was realized through acid‐base control. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014, 52, 2669‐2683

No abstract

Polyhedral oligomeric silsesquioxane (POSS)-containing homopolymers (PHEMAPOSS) with a high degree of polymerization (DP) were synthesized via reversible addition–fragmentation chain transfer (RAFT) polymerization. PHEMAPOSS was used as a macro-RAFT agent to construct a series of amphiphilic diblock copolymers, PHEMPOSS-b-PMAA (poly (methyl methacrylate)), which possessed a different length of hydrophilic chains. The self-assembly behavior of PHEMPOSS-b-PMAA in aqueous solution was studied by transmission electron microscopy (TEM), atomic force microscopy (AFM), and dynamic light scattering (DLS), respectively. The results showed that PHEMAPOSS45-b-PMAA523 forms typical core–shell spherical micelles where the hydrophobic PHEMAPOSS blocks as the core and hydrophilic PMAA blocks as the shell. With increasing PMAA chain length, PHEMAPOSS45-b-PMAA1173 with a longer PMAA chain self-assembled into irregular aggregates with POSS moieties dispersed in the aggregates. On the other hand, PHEMAPOSS45-b-PMAA308 with a shorter hydrophilic PMAA chain could self-assemble into a dendritic cylinder structure.