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The basic purpose of curare and curare‐like drugs is to produce muscular relaxation and facilitate endoscopy. The use of these drugs is discussed. The necessary cautions in the preparation of the patient and the precautions to take in case of emergency are enumerated. A technique of administration is suggested. The pharmacologic properties of d‐tubocurarine, Di‐methyl tubocurarine iodide, decamethonium bromide and flaxidil are compared. Clinically and experimentally, Di‐methyl tubocurarine iodide is the drug of choice