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Magnetic hyperthermia is very promising cancer therapy in which heating temperature is expected to be a key determinant for its success. Herein, we present a simple, real-time, and high-accuracy proportional-integral-derivative-based temperature control system for magnetic hyperthermia using widely-used induction heater and fiber optic thermometer. Our in vitro result shows that the temperature of clinically-approved Resovist ® (0.5 ml) was accurately controlled with very small overshoot (e.g., 45.0 ± 0.07 • C and 55.0 ± 0.11 • C for low-and high-temperature magnetic hyperthermia). Our system has the potential to be used for magnetic hyperthermia either alone or together with other cancer treatment modalities for basic and clinical studies.

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