The aim of this study was to determine whether feed supplementation with nanoencapsulated Ph2Se2 would improve the growth performance of silver catfish and would maintain or improve the muscle antioxidant system. Final mean weight (p = .031), weight gain (p = .014) and specific growth rates (p = .045) were significantly higher in supplemented fish than in the control group. Muscle reactive oxygen species (p = .0001) levels were significantly lower in supplemented fish than in the control group. Also, muscle hydrogen peroxide (p = .0001) and lipid peroxidation (p = .0001) levels were significantly lower in supplemented fish than in the control group. Muscle antioxidant capacity against peroxyl radical (p = .00001) levels were significantly higher in fish supplemented with both Ph2Se2 forms (free or nanocapsules) than in the control group, while muscle superoxide dismutase (p = .001) and catalase (p = .0001) activities were significantly higher in supplemented fish than in the control group. Finally, selenium (Se) deposition (p = .00001) was significantly higher in the muscle of fish supplemented with free and nanoencapsulated forms compared with the control; and deposition levels were significantly higher in fish supplemented with Ph2Se2‐loaded in nanocapsules compared with the free form. Based on this evidence, Ph2Se2‐loaded in nanocapsules improves silver catfish performance and antioxidant/oxidant status. The greater content of Se (1.22 µg/g muscle) in the muscle of fish fed with dietary Ph2Se2‐loaded nanocapsules indicates that it may be considered a nutraceutical for fish.
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