Religiosity/spirituality is generally considered as a powerful tool for adjusting and coping with stressors, attributing purposes and meanings (either existential/philosophical, cognitive, or behavioral ones) to daily situations and contexts. While studies generally investigate these effects in Judaism and Christianity believers, there is a dearth of data concerning oriental religions. We sampled from Italian Nichiren Buddhists, the most widespread branch of Buddhism in Italy (n = 391). Participants were Buddhists on average since 5 years and self-defined moderate practitioners. Adaptive strategies exhibited higher scores than maladaptive ones. Specifically, the adaptive strategy of active coping positively correlated with self-evaluated degree of being a practicing Buddhist, as well as positive reframing and religion, while maladaptive strategies such as use of substances, venting and behavioral disengagement correlated negatively. Only the subscale of religion correlated significantly and positively with the time from which the participant had become Buddhist, while the use of emotional support correlated negatively. Most participants had a predominantly internal locus of control. External locus of control negatively correlated with time the participant became Buddhist and the self-reported degree of being a practicing Buddhist, whereas internal locus positively correlated only with the latter variable. Furthermore, Buddhist participants exhibited a low psychopathological profile when compared with the normative scores.