Background: The level of job satisfaction affects not only the quality of the function exercised by the nurse, but also patient satisfaction, therefore it is very important for health care institutions to measure these perceptions amongst nurses. Aim of the study: This research had assessed the job satisfaction among nurses in the Public Hospital Vlora, Albania and the contributing factors on it. Method: Data of this cross-sectional research were collected using a questionnaire which measures job satisfaction, based on Mueller and McCloskey Satisfaction Scale (MMSS), adapted. Results: The professional pleasure that nurses sense to their profession is close to neutral (x = 2.92), with the trend to dissatisfaction. Most important extrinsic factor that affects the intensity of satisfaction in the nursing profession is 'monthly payment' (4.5 points), while as the most important intrinsic factor is ranked "career escalation" (3.84 points). Conclusions: In conclusion, we can say that the level of professional satisfaction among nurses involved in this study was below the average. Less satisfied groups from nursing profession were young people and high educated nurses. The low level of professional gratifying is expressed as well in the fact that over 70% of nurses in the study would like to practice another profession.