No abstract

[251I-Tyr8]-substance P and [251I]-neurokinin A binding assays in conjunction with tachykinin-receptor selective agonists ([Sar9Met(02)"]substance P for NK, and [PAla8]neurokinin A (4-10) for NK2) and antagonists (CP-99,994 for NK, and SR48968 for NK2). 2 The presence of high affinity, G-protein-coupled NK, receptors in guinea-pig lung parenchymal membranes has been confirmed. The rank order of affinity for competing tachykinins was as predicted for an NK, receptor: substance P = [Sar9Met (02) 6 In summary, these data demonstrate that guinea-pig lung parenchyma and guinea-pig trachea express both NK, and NK2 receptors.