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SYNOPSIS C-Reactive protein has not been studied in malaria so far but with the reappearance *of malaria in the southern part of Iran there is now an opportunity to study the behaviour of C-reactive protein in malaria. One hundred and sixty-two patients suffering from malaria have been so tested. Of those patients, 85-2% showed a positive result and among them more than 50% had a strongly positive reaction. It may be concluded that malaria is one of the outstanding diseases in which the C-reactive protein test is positive. Those patients who were examined for C-reactive protein in the first two days of the disease showed a negative result.

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