Die Reaktion des Methoxyderivates (II) mit Methanol erfolgt in neutraler Lösung reversibel unter Ringöffnung und Weiterreaktion zu (III) und (IV).

1985) AN ANSWER TO THE SPIRO VS ANSA DILEMMA IN CYCLOPHOSPHAZENES. PART VIII. THE FIRST FUSED DISPIROCYCLOTRIPHOSPHAZENES, N 3 P 3 CL 2 [HN[sbnd](CH 2 ) m [sbnd]NH] [HN[sbnd] (CH 2 ) N [sbnd]NH](m ≠ n = 2,3,4), Phosphorus and Sulfur and the Related Elements, 25:3, 273-287, AN ANSWER TO THE SPIRO VS ANSA DILEMMA IN CYCLOPHOSPHAZENES. PART VIII*. THE FIRST FUSED DISPIROCY CLOTRIPHOSPHAZENES, [HN-(CH2)n-NH](m f n = 2,3,4). The synthesis of the first fused DISPIROcyclotriphosphazenes was achieved upon reaction of a diamine H,N-(CH,)m-NH, (,with m = 2.3,4) on the N,P,CI,[HN-(CH2),-NH2](with n # m ) MONOSPIRO derivative in stoichiometric conditions. Molecular structures were ascribed by using both P and I H high resolution NMR and electron-impact mass spectrometry. The chemical shift of the phosphorus atoms bearing the loop varies linearly with the value of the corresponding NPN endocyclic angle. The synthesis of this fused derivatives occurs in quantitative yield. It leads the way for the covalent binding at demand on a cyclophosphazene antitumoral system of several natural polyamines as tumor finders in the SPIRO configuration.

The synthesis of new derivatives of bis-( tetrachlorocyclotriphosphazeny1)-spermine was achieved upon reaction of some MONOSPIRO-N3P3CI,[HN-(CH2),-NH] ( n = 2,3,4) derivatives and of the gem-N3P3Az2C1, with spermine. AU compounds were obtained in the monomeric state. 'lP and 13C high-resolution NMR were used, together with IR spectroscopy and mass spectrometry, to assign molecular structures and to reveal conformational equilibria, if any.

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