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An electron microscopic procedure has been developed, using rat liver, for the localization of hormone-sensitive adenyl cyclase. Isoproterenol-sensitive adenyl cyclase is located almost exclusively in the parenchymal cells. In contrast, glucagon-sensitive adenyl cyclase is located primarily in the reticulo-endothelial cells but is also present in parenchymal cells. Sodium fluoride-sensitive adenyl cyclase is found in both cell types.

SYNOPSIS Four patients developed cluster headaches after minor head injuries that caused no permanent neurologic or CT abnormalities. None had had headaches previously. The headaches of the three whose histories were known in detail either corresponded to the injury site or evolved from an earlier headache that did. Nerve injury is suggested as the mechanism by which trauma could initiate cluster headache.

SYNOPSIS One hundred consecutive headache clinic patients were evaluated prospectively for features of the temporomandibular joint (TMJ) pain‐dysfunction syndrome. The syndrome was identified in 14, mainly young women, who differed significantly in physical findings and headache associated symptoms from those with tension or vascular headache, but not in the frequency of anxiety‐relieving chronic oral habits usually said to be causal. They resembled tension headache patients in their high incidence of associated depression, and most improved following treatment with physical therapy and tricyclic antidepressants. Radiologic joint abnormalities were uncommon. The TMJ pain‐dysfunction syndrome appears to be a frequent, easily diagnosed, and easily treated, but usually unappreciated cause of headache distinct from other headache entities.

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