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The largest and most effective class of tyrosine hydroxylase inhibitors is made up of tyrosine analogs.

A number of 2‐substituted 4,5‐dihydroxy‐6‐(substituted aminomethyl)pyrimidines (VIII) were prepared from the corresponding 2‐substituted 4,5‐dihydroxypyrimidines (VII) by a new pyrimidine Mannich reaction. The structure of VIII was proved by an independent synthesis. Further study of this reaction led to the synthesis of a new class of compounds: the pyrimido[4,5‐e]dihydro‐1,3‐oxazines (VI).

The biogenetic relationship between purines and pteridines has been described.2 Since 2,6-diaminopurine, which inhibits the growth of leukemia,8 is (1) (a) This investigation was supported by Contract No.