Figure 2. Magnetic resonance image of the left thigh, short-T1 inversion recovery sequence, showing a diffuse thickening and hypersignal of the fasciae that is consistent with active fasciitis (red arrows). Figure 3. Optical microscopy image showing marked inflammatory infiltrate of the fasciae (red arrow) (hematoxylin and eosin; original magnification, Â20).

AKI during high-dose cloxacillin treatment mostly occurs in elderly patients taking concomitant nephrotoxic drugs. The outcome is usually favourable after cloxacillin discontinuation. Therapeutic drug monitoring may decrease the risk of AKI in patients treated with high-dose cloxacillin.

We proposed an information retrieval-based method for detecting drug-induced anaphylaxis, by querying structured and unstructured data in a CDW. CDW queries are less specific than spontaneous reporting and Diagnosis-related Groups queries, although their sensitivity is much higher. CDW queries can facilitate monitoring by pharmacovigilance experts. Our method could be easily incorporated in the routine practice.

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