The objectives of this study were to assess the psychometric properties of the Orientation to Life Questionnaire (OLQ) and to investigate the differences in sense of coherence among demographic groups in a chemical factory environment. The OLQ and a biographical questionnaire were administered to chemical factory employees (N = 583). A three-factor model (manageability, meaningfulness and comprehensibility) was confirmed through structural-equation modelling. From the original 29-item OLQ, an 11-item OLQ and a 6-item OLQ were first derived with good fit statistics. With the 11-item OLQ, significant differences in sense of coherence among some demographic groups viz. qualification and job level were then confirmed.