A series of trans‐2,3‐dihydrofuro[3,2‐c]coumarins (4) has been synthesized by a one‐pot multicomponent reaction by aromatic aldehydes, 4‐hydroxycoumarin, α‐tosyloxyketones, and pyridine using triethylamine as catalysts in acetonitrile. The synthesized compounds were then screened for their antioxidant and anthelmintic activities.

A selective synthesis of 3-(α,α-dibromoacetyl)-4-hydroxy-6-methyl-2H-pyran-2-one (3) has been achieved by bromination of DHA using CuBr 2 /CHCl 3 -EtOAc. The reaction of 3 with different thioureas/thiomides/thiosemicarbazide offers a convenient and efficient method for the syntheses of 2-substituted 4-(4-hydroxy-6-methyl-2H-2-oxopyran-3-yl)thiazoles. These thiazoles were evaluated for their antimicrobial and antifungal activity.

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Hydroxy(tosyloxy)iodo]benzene (HTIB, PhI(OH)OTs) is a versatile hypervalent iodine(III) reagent that has numerous applications in organic synthesis [1].

Some products exhibit anthelmintic or antioxidative properties comparable to standard drugs.