Numerical simulation method of the internal flow field of fluid machinery has become an important technology in the study of fluid machinery design. In order to obtain a high-performance cement slurry mixer, computational fluid dynamics (CFD) techniques are used to simulate the flow field in the mixer, and the simulation results are studied. According to the analysis results, the structural parameters of the mixer are modified. The results show the mixer under the revised parameters meet the design requirements well. So CFD analysis method can shorten design period and provide valuable theoretical guidance for the design of fluid machinery.