One of the challenges for the patients diagnosed with major depression is not to experience relapse or reoccurrence which are very common characteristics of major depression. Providing constant monitoring of these patients during their daily life for the first year of their depression can have a significant impact on preventing these patients to experience reoccurrence and relapse. In this paper we describe an intelligent remote monitoring system that is in the process of development and present the new research done centered on the interaction between the system and the actors involved, i.e. patients, psychiatrists and primary care physicians. This interaction is done through an android application for mobile telephones and a Website. The specification and design of the information requested and submitted to system actors through both platforms is performed by the communication module, which is also described in this research.