Health is the ultimate gift from Allah SWT. Therefore, taking care of our health is a priority. When someone is sick, he or she needs to search for medication as an effort to relieve the pain. Nevertheless, arguments had been raised by Muslims about the permissibility and lawfulness (halal) of our medication from the Islamic point of view. Abundance of information had been lingering around questioning about the halal status of our medication that makes many Muslims in dilemma. Therefore, this paper aimed to present the general Shariah guidelines on the halal status of common medicine used by Muslims in Malaysia. The paper also discussed several issues related to halal medicine and medication intake. The paper proposed for the respective parties and authorities to take halal issue seriously in order to safeguard the welfare and interest of the public.