Highlights d InfinityFlow protein expression analysis reveals DC-and monocyte-specific markers d Monocytes are CD88 + CD89 + , while cDC2s are HLA-DQ + FcεRIa + d cDC2s comprise CD5 + DC2s and CD5 À CD163 +/À CD14 +/À DC3s d Pro-inflammatory CD14 + DC3 expansion correlates with disease activity in SLE patients

Increased NET release is associated with autoimmunity and inflammation in SLE and APS. Inhibition of NET release thus could be of potential benefit in a subset of patients with SLE and APS.

Our findings showed that miR-483-5p is up-regulated in the serum of SSc patients, from the early stages of the disease onwards, and indicated its potential function as a fine regulator of fibrosis in SSc.