Objective:
Subarachnoid hemorrhage is a prevalent disease with high morbidity and mortality. Numerous complications contribute to brain injury and defy the clinical practitioner on diagnosis and management. Valproate-associated hyperammonemic encephalopathy is a rare, underdiagnosed, serious and important entity to consider. We present a case of a patient with subarachnoid hemorrhage who received anticonvulsant prophylaxis with valproate and developed neuroworsening associated with high levels of ammoniemia and periodic discharge electroencephalographic patterns without other identifiable causes. Discontinuing valproic acid treatment and normalization of ammoniemia resulted in improvement in clinical and electroencephalographic neurological status.
El síndrome de Lemierre constituye una entidad poco frecuente y potencialmente grave que puede complicar una infección orofaríngea. Incluye una tromboflebitis de la vena yugular interna y embolias sépticas a distancia. Presentamos el caso clínico de un hombre joven que se presentó, luego de una infección respiratoria alta, con una trombosis de vena yugular interna, seno sigmoideo y transverso izquierdos, asociando además tromboembolismo pulmonar séptico y empiema pleural. Mostró buena evolución con antibioticoterapia empírica, drenaje pleural y anticoagulación.Realizamos una revisión de la literatura sobre este tema enfatizando los aspectos clínicos, epidemiológicos y microbiológicos.
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