Colorectal cancer (CRC) is a global public health problem as it is the third most prevalent and the second most lethal cancer worldwide. Major efforts are underway to understand its molecular pathways as well as to define the tumour-associated antigens (TAAs) and tumour-specific antigens (TSAs) or neoantigens, in order to develop an effective treatment. Cell therapies are currently gaining importance, and more specifically chimeric antigen receptor (CAR)-T cell therapy, in which genetically modified T cells are redirected against the tumour antigen of interest. This immunotherapy has emerged as one of the most promising advances in cancer treatment, having successfully demonstrated its efficacy in haematological malignancies. However, in solid tumours, such as colon cancer, it is proving difficult to achieve the same results due to the shortage of TSAs, on-target off-tumour effects, low CAR-T cell infiltration and the immunosuppressive microenvironment. To address these challenges in CRC, new approaches are proposed, including combined therapies, the regional administration of CAR-T cells and more complex CAR structures, among others. This review comprehensively summarises the current landscape of CAR-T cell therapy in CRC from the potential tumour targets to the preclinical studies and clinical trials, as well as the limitations and future perspectives of this novel antitumour strategy.

RESUMO Las formas de extractivismos se multiplican y diversifican, transformando de manera radical los territorios donde se instalan, como expresión del pensamiento de la modernidad insostenible y del pensamiento colonialista. Esto nos ha llevado a una crisis ambiental-civilizatoria con diversas expresiones en sus distintos campos. Dentro de los mismos, se encuentran las tensiones y desafíos al interior del campo del conocimiento científico académico. En el artículo se describen y analizan los aportes de la perspectiva de la Ecología Política Latinoamericana y la Salud Colectiva, a través de las categorías de Territorio, Salud Socioambiental, y Soberanía Alimentaria para la comprensión de los procesos salud-enfermedad-atención-cuidado en los contextos actuales.