Health is the greatest treasure of every individual in today's society. People who have good health have better conditions to achieve their goals than those with various physical and mental difficulties. They create the basic development potential of different hierarchical regions. Tumor diseases in the world's economically advanced countries are the second most common cause of death after cardiovascular disease. These diseases are the main cause of mortality, particularly early and disability, in many regions. The aim of the contribution is to identify, on the basis of mortality and incidence development, regions with a high incidence of cancer. Cancer diseases known as cancer are the second most serious cause of death with a share of 25,35% (2017) in Slovakia as well. Slovakia belongs besides Hungary and Croatia to the three countries in the EU with the highest mortality rates for cancer. In 2017, 13,666 people died of this disease. The number of reported new cases is constantly increasing. In order to establish effective preventive measures for primary and secondary prevention, it is necessary to know the level of mortality and incidence of cancer in the regions of Slovakia, which is the purpose of the contribution.