Tese apresentada à Faculdade de Ciências Médicas da Universidade Estadual de Campinas como parte dos requisitos exigidos para a obtenção do título de Doutora em Ciências na Área de Clínica Médica. Thesis presented to the Faculty of Medical Sciences of the State University of Campinas as part of the requirements required to obtain the Doctor in Science, Clinical Medical Area.
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