Highlights * Piperazinyl-ureido sulfamates were designed and synthesised. * Synthesised compounds were assayed in vitro as steroid sulfatase (STS) inhibitors. * Synthesised compound inhibited STS with micromolar to low nanomolar potency. * Selected STS inhibitors are membrane permeant in a JEG-3 human placenta choriocarcinoma cell line. * The sulfamates 19 and 20 had STS IC50 values of 5.1 and 8.8 nM respectively.
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