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Highlights d fMRI networks in awake mice depart from underlying anatomical structure d fMRI dynamics in wakeful mice is critically shaped by arousal-related nuclei d Occurrence and topography of rsfMRI coactivation patterns define conscious states d fMRI coactivation dynamics defines a signature of consciousness in the mouse brain

Highlights d Mouse resting-state default mode network anatomy described at high resolution in 3D d Systematic axon tracing shows cortical DMN regions are preferentially interconnected d Layer 2/3 DMN neurons project mostly in the DMN; layer 5 neurons project in and out d Retrosplenial cortex contains distinct types of in-and out-DMN projection neurons