Understanding what the Working Memory is, how it works and how it is related to learning is very important for education. Objectives: To determine the relationship between working memory and the academic performance of medical students. Methodology: A cross-observational study, of a descriptive correlational type, was carried out. The design is retrospective-retrolective with a non-probabilistic sample for convenience with prior signature of informed consent with a total of 270 students of the UJED School of Medicine. Contribution: In the results obtained, no significant correlation was found between working memory and academic performance, however, a high percentage (53.3%) of students who have attended at least one subject were observed and they have better grades than the group that has not studied subjects, for that reason a second analysis was carried out by means of comparative test with U Mann-Withney, finding a significant difference between the qualifications of the groups with a p=.000, not so far the memory components of working memory which were found within normal values according to the brief neuropsychological test in Spanish.