BackgroundGeranium bellum Rose, locally known as “Pata de león”, is a perennial plant distributed in the mountains of Hidalgo, Mexico. It is widely used in Mexican traditional medicine to treat fever, pain, and gastrointestinal disorders. To date, there are not published studies regarding the in vivo antinociceptive and anti-inflammatory potential of the acetone-aqueous extract from the aerial parts of G. bellum.MethodsAntinociceptive effects of the acetone-aqueous G. bellum (AGB) extract and the isolated compounds were assessed using experimental pain models, including thermal nociception like hot plate test, and chemical nociception induced by intraperitoneal acetic acid or subplantar formalin injection in vivo. The anti-inflammatory properties of the extract were studied using systemic administration in carrageenan-induced paw edema.ResultsIntra-gastric administration of AGB (75, 150, and 300 mg/kg) showed a dose-dependent antinociceptive effect in intraperitoneal acetic acid (writhing), thermal nociception in CD1 mice, and subplantar formalin models, as well as anti-inflammatory effect in carrageenan- induced paw edema in Wistar rats. Geraniin and quercetin showed the highest antinociceptive activity in writhing test, whereas ellagic acid was the most active compound in the hot plate model.ConclusionThese studies provide evidences that G. bellum shows antinociceptive and anti- inflammatory effects, and gives support to its use in treating pain in Mexican traditional medicine.

BCRIHH Bloqueo completo de la rama izquierda del haz de His CAT Curva de actividad-tiempo ECG Señal electrocardiográfica FaPI Imagen factorial de fase FaPIm Imagen factorial de fase propuesta FCG Señal fonocardiográfica FEVI Fracción de expulsión del ventrículo izquierdo FoAI Imagen de amplitud por Fourier FoPI Imagen de fase por Fourier IC Insuficiencia cardíaca IDT Imagen de Doppler tisular IST Imagen de speckle tracking MCD Miocardiopatía dilatada primaria NYHA New York Heart Assosiation OAI Oblicua anterior izquierda RCD Robot cardiaco dinámico RMC resonancia magnética cardiovascular ROI Región de interés V SA sinusal strain rate velocidad de deformación SVD Descomposición en valores singulares Tc-99m Tecnecio 99 metaestable TRC Terapia de resincronización cardiaca VD Ventrículo derecho VI Ventrículo izquierdo VRIE Ventriculografía radioisotópica en equilibrio

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