We investigated the anti-inflammatory, antinociceptive and ulcerogenic activity of a zinc-diclofenac complex (5.5 or 11 mg/kg) in male Wistar rats (180-300 g, N = 6) and compared it to free diclofenac (5 or 10 mg/ kg) and to the combination of diclofenac (5 or 10 mg/kg) and zinc acetate (1.68 or 3.5 mg/kg). The carrageenin-induced paw edema and the cotton pellet-induced granulomatous tissue formation models were used to assess the anti-inflammatory activity, and the Hargreaves model of thermal hyperalgesia was used to assess the antinociceptive activity. To investigate the effect of orally or intraperitoneally (ip) administered drugs on cold-induced gastric lesions, single doses were administered before exposing the animals to a freezer (-18ºC) for 45 min in individual cages. We also evaluated the gastric lesions induced by multiple doses of the drugs. Diclofenac plus zinc complex had the same anti-inflammatory and antinociceptive effects as diclofenac alone. Gastric lesions induced by a single dose administered per os and ip were reduced in the group treated with zinc-diclofenac when compared to the groups treated with free diclofenac or diclofenac plus zinc acetate. In the multiple dose treatment, the complex induced a lower number of the most severe lesions when compared to free diclofenac and diclofenac plus zinc acetate. In conclusion, the present study demonstrates that the zincdiclofenac complex may represent an important therapeutic alternative for the treatment of rheumatic and inflammatory conditions, as its use may be associated with a reduced incidence of gastric lesions. Correspondence

Oral administration of tenoxicam or zinc-tenoxicam complex inhibited to a similar extent carrageenin-induced paw oedema and granulomatous tissue formation in rats as well as the acetic acid induced writhing response in mice. Gastric lesions induced by oral administration of zinc-tenoxicam were reduced in number and severity when compared with those induced by tenoxicam or the co-administration of tenoxicam and zinc acetate. However, after intraperitoneal administration, both zinc-tenoxicam and tenoxicam plus zinc acetate induced a reduced number of gastric lesions as compared with tenoxicam.

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Este estudo tem como objetivo avaliar cinco métodos de previsão para demanda intermitente usando uma série histórica de consumo de peças sobressalentes da aeronave 737 Next Generation, fabricado pela Boeing, da maior frota aérea brasileira gerenciada pela VRG Airline Company S/A. Os métodos de Winter, Croston, Single Exponential Smoothing, Weight Moving Average e Método de Distribuição de Poisson foram testados em um histórico de 53 peças sobressalentes e cada uma delas possui um histórico de demanda de trinta e seis meses (janeiro de 2013 a dezembro de 2015). Os resultados mostraram que os métodos Weight Moving Average, Distribuição de Poisson e Croston apresentaram os melhores ajustes. Além disso, observou-se que a maior parte das demandas por peças sobressalentes apresentaram um padrão smooth ao contrário do resultado obtido pelo estudo de Ghobbar and Friend (2003) que apresentou um padrão lumpy. Por outro lado, tem-se que o Método de Winter apresentou-se como o de pior ajuste em ambos os estudos. Conclui-se que os métodos de Weight Moving Average e Distribuição de Poisson são os mais adequados para avaliar a demanda intermitente para o caso da VRG Airline Company S/A.