In spite of the first trials on the effect of cholesterol reduction and its beneficial impact on morbidity and mortality in the elderly many have already proven the antecipated positive results. The high risk attributable to the elderly is a guarantee for an effort in primary prevention, especially when a high level of serum cholesterol is combined with other risk factors linked to coronary artery disease. There are elements of similarity for primary prevention in the elderly over 65 years of age, compared to middle-aged patients. This consideration opened the need for scientific evidence with confirmed levels of evidence. The first studies were WOSCOPS, AFCAPS/TEXCAPS, Heart Protection Study, PROSPER, ALLHAT (Antihipertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial-Lipid Lowering Trial), REVERSAL, Health Study, ASCOT (Anglo Scandinavian Cardiac Outcomes), MIRACL, Post CABG, AVERT, ACCESS, ASSET, ATGOAL, CHALLENGE, CURVES, BELLS, ARBITER, NASDAC, PROVE-IT and DEBATE. Positive evidences were shown from the first to the last trial recalled in this historical beginning.
Serviço de Clinica de Doenças Tropicaes e Infectuosas do Prof. Celestino Bourroul Considerações em torno de um caso de "Mal de Roger" Fuad Chammas e Luiz Kencis Terceiroannistas Entende-se sob a denominação de MAL DE ROGER, uma mal-formação cardíaca, que consiste em verificar-se comunicação interventricular determinada por um orifício situado em geral, na parte antero-superior do septo inter-ventricular, na "pars membranacea" deste mesmo septo, mal-formação esta descripta pela vez primeira em 1879 por Roger, á qual emprestou o nome. Por via de regra, perturbação alguma outra enquadrada nas malformações congênitas do coração, acompanha o MAL DE RO-GER, havendo sempre todavia neste caso passagem de sangue arterial do Ventriculo esquerdo, onde é maior a pressão para o direito onde é ella menor, razão pela qual esta malformação é desacompanhada de cyanose.
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