Background: The skin is the organ that covers the entire human body and serves to protect the body from outside influences, so that the skin needs to be protected. The process of destruction of the skin characterized by the appearance of wrinkles, dried and cracked. Skin damage can occur due to the sun's rays. Antioxidants are needed to prevent, inhibit structural damage of the skin. This study aims to determine the best concentration from a combination of Clitoria ternatea L. flower extract and dragon fruit (Hylocereus Polyrhizus (F.A.C. Weber) Britton & Rose) peel extract in lotion formulation. The research was conducted by making extract preparation and formulate in lotion by differentiating its concentration F1 (5%:5%), F2 (3%:6%), F3 (7%:3.5%). The results:  Lotion of combination Clitoria ternatea L flower and dragon fruit peel extract with concentration F3 (7%:3.5%), showed the best effect, because it gives higher moisture increase compared to initial conditions, from to 32.6% become 65.2% after 4 weeks of usage. The conclusion: Combination Clitoria ternatea L. flower and dragon fruit peel extract can be formulated as a moisturizing lotion and with best combination in 7%: 3.5%. Keywords: Lotion, Combination, Extract, Flower Clitoria ternatea , Dragon Fruit Peels