Oxidized LDL cholesterol (ox-LDL) is considered to be a key factor of initiating and accelerating coronary heart disease CHD and diabetes Mellitus DM , is associated with several mechanisms one of them Oxidative stress. The aim of this study was to find the association between ox- LDL ,HDL-C , TG , LDL-C and arylesterase , with CHD risk in different age groups in males and females , the difference in these risk factors can explain the sex difference and how much the changes in the risk factors levels in CHD and CHD with DM patients between age groups. Methods: determination biochemical parameters of serum blood of ox-LDL , TG , TC , HDL-c , LDL-c , S. Glucose and arylesterase activity were measured in cases male and females were carried CHD and CHD with DM .The cases divided in different the age  groups (40-49) , (50-59) and (60-69) years and compered the result with control groups . Results: mean Value of ox-LDL and oxidation ratio of LDL show significantly higher at (p<0.05) in CHD and (p<0.001) in CHD with DM patient for females  in the age group (40-49) years but in the males show the results significant decrease  and different significant in others groups ,beside to effect Sex and age some the studied biochemistry parameters levels and signification decrease in HDL-C and arylesterase levels as antioxidant enzymes in females and male patient selected compared with control groups.

The extraction of arylesterase from the aqueous extract of (peel and pulp) of Annona muricata fruit was conducted using different biochemical techniques. It was shown that, max activity was obtained in the pulp than in peel, and by using gel filtration chromatography on sephadex G-75 for the pulp part, the solution of the proteinous precipitate produced by acetone precipitation, contained three proteinous peaks. The activity for peak A (1653) and peak B(2310.9) but the third peak C was very low. while maximum specific activity was obtained in the second peak (B) which showed (23107), (18366) IU/ml /mg for (A) and very low for the third one (C), and (12.58),(26.531) folds of purification for B and A peaks respectively .Furthermore, the comparative molecular weight of the partially purified isoenzymes arylesterase

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