Sinonasal malignant neoplasms are rare and heterogeneous tumors of sinonasal tract, constituting about 3% of the upper respiratory tract tumors. A variety of gene products encoded by Human herpes Virus -8,are involved in transformation, as well as promotion of oncogenesis. angiogenesis, anti-apoptosis, and immune modulation and evasion. The aim is to unravel the ratesof Human herpes Virus -8 (HHV-8) infections in tissues from a group of patients with sinonasal carcinoma (SNC) and sinonasal papilloma (SNP). Eighty-three formalin-fixed, paraffin-embedded sinonasal carcinoma (SNC) and sinonasal papilloma (SNP)tissues enrolled in this study; 18 sinonasal tissue biopsies from sinonasal carcinoma; 35 tissue biopsies from sinonasal papilloma and 30 apparently healthy nasopharyngeal tissues with unremarkable pathological changes, as control group. Detection of HHV-8 was done by new detection version of chromogenic in situ hybridization (CISH) technique. The positive CISH reactions for HHV-8-DNA were detected in 22.2% and 5.7% of sinonasal carcinoma and sinonasal papilloma tissues, respectively. And no control tissues presented positive signals for HHV-8-CISH test. The correlation between HHV-8 and sinonasal carcinoma and sinonasal papilloma was highly significant (P= 0.001). The significant HHV-8 detection rates in sinonasal carcinoma and sinonasal papilloma tissues might shade light for a possible role of this virus in either sinonasal pathogenesis or carcinogenesis.