Sarang semut (Myrcomedia pendans) is traditional medicine plant that has been widely used as alternative treatment for diabetics and cancer. Flavonoids in sarang semut ectract known as active copounds for pharmacology activity, and it has low solubility in water. The methods can be used to improve the availability of water-insoluble compounds for better to deliver the active compounds into the body is SNEDDS (Self –Nanoemulsifying Drug Delivery System). The purpose of this study is to get the formulation and characterized of SNEDDS of sarang semut. The parameters used were particle size, polydisperse index (PI), zeta potential. The results showed capryol 90 as oil vehicle, tween 80 as the surfactant, and propylene glycol as co-surfactant, and particle size is 12.53 nm, the polydisperse index is 0.27 Ð and value of zeta potential is -51, 43 mV. Physical stability of the three formula has shown good results. MTT Assay test results obtained with an amount of 258.755 ppm and 389.955 ppm are included in the range of toxic enough for IC50 is in the range ≤ 1000 ppm. The results obtained show that the sarang semut SNEDDS have good physical and chemical properties, has good organoleptic and have an inhibitory effect on the activity of Hela cells.