Background: This work aims at describing the traditional uses, to determine the antimicrobial potential of two different extracts hexane, acetone of the leaves of Citrus unshiu, Citrus sinensis, Citrus limon, Laurus nobilis, Citrus paradisi on clinical strain of H. pylori in a bid to identify potential sources of cheap starting materials for the synthesis of new drugs. H. pylori strain was a culture collection of Hacettepe University, Turkey. Methods: The activity was quantitatively assessed on the basis of the inhibition zone, and their activity index was also calculated along with the MIC method.