Covid-19 is a pandemic disease • Indigenous populations are more vulnerable to COVID-19 due to social, environmental and health factors. • A health system with a communitybased scheme must be strengthened. • Mexico has government programmes that could be reorganized to meet the needs of the indigenous population.

Background: The 14-3-3 test appears to be a valuable aid for the clinical diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) in selected populations. However, its usefulness in routine practice has been challenged. In this study, the influence of the clinical context on the performance of the 14-3-3 test for the diagnosis of sCJD is investigated through the analysis of a large prospective clinical series.