The data of the literature on the structure and physiology of the vitreous body and the retina in normal and pathological conditions are presented. The mechanism of vitreous detachment and its role in the development of vitreoretinal proliferation are described. Described adren-choline-peptide and NO-ergic mechanisms in signal transduction of the vitreous body and retina. Pharmacological and surgical methods of treatment of vitreoretinal proliferation are briefly described.

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Background: Serotonin (5-hydroxytryptamine, 5-HT) is a regulatory and biologically active neurotransmitter and a hormone in the CNS and many organs, including the esophagus. It is known that serotonin as well as acetylcholine stimulates contractile activity of the esophageal smooth muscles. However, role of different serotonin receptors in realization of large doses of serotonin in contractile activity of the esophagus is insufficiently known. Aim: To determine receptor mechanisms in realization of large doses of serotonin in contractile activity of the esophagus.