Adibenzofuran-based/~-turn mimic has been incorporated in the B12-29 fragment of the B1 domain of streptococcal protein G. This amino acid sequence adopts a/]-hairpin structure in the complete B1 domain (Bla-56). The modified peptide was studied by CD and NMR spectroscopy and its solution behavior was compared with the conformation adopted by the same sequence in the modified B1 domain.
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