Care and troubleshooting of peripherally inserted central catheters (PICCs) are essential practices of all bedside nurses. PICC usage has increased over the past 5 years. Unfortunately, PICC education has not been encouraged for nurses despite this escalation. The authors examined the differences in staff knowledge, confidence, and psychomotor skills, with PICC care and troubleshooting before and after a focused PICC educational intervention. It was hypothesized that education would increase all of these components. A pretest, a posttest, a Likert scale, and a skill checklist were the tools used to assess the study participants. Study results revealed a significant increase in the nurse's PICC knowledge, confidence, and psychomotor skills. PICC educational programs are vital for nurses who care for and troubleshoot PICCs.