This paper evaluates the accessibility of selected field and laboratory high school science activities, and provides suggestions for increasing accessibility for students with disabilities. We focused on GLOBE (Global Learning Observations to Benefit the Environment) protocols, specifically the new Seasons and Biomes investigation currently being developed as part of the GLOBE program. Five university students with disabilities majoring in science or technology were recruited to test the GLOBE protocols, and 10 protocols were evaluated for accessibility. Based on our results, we make several suggestions with regards to instructions, equipment, safety, outcomes and activity significance that will increase the accessibility of GLOBE and all K-16 science methods.