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This paper presents a new Interference Alignment (IA) scheme for K-User Multiple Input Multiple Output (MIMO) Interference Channel (IC) based on two metaheuristics, namely Particle Swarm Optimization (PSO) and Artificial Bee Colony (ABC) Algorithm. Tackling interference is an essential issue in wireless communications to which Interference Alignment (IA) provides a promising solution. However, IA still lacks of explicit and straightforward design procedures. In fact, most of IA procedures aim to minimize a certain Interference Leakage (IL) which measures the effect of the interference on the network, this results in complex optimization tasks involving a large amount of decision variables, together with a problem of convergence of the IA solutions. In this paper the IA optimization is performed using PSO, ABC and their cooperative counterparts, more suitable for large scale optimization. A comparison between the four algorithms is also carried out. The cooperative proposed approaches seem to be promising.