УДК 371.3 UDC 371.3 13.00.00 Педагогические науки Pedagogical sciences РАЗРАБОТКА ДИСТАНЦИОННОГО КУРСА В ОБРАЗОВАТЕЛЬНОЙ СРЕДЕ MOODLE THE DEVELOPMENT OF A DISTANCE COURSE IN THE MOODLE EDUCATIONAL ENVIRONMENT Смирнова Анна Сергеевна Smirnova Anna Sergeevna к.п.н., доцент по кафедре высшей математики и методики преподавания математики

The rheological behavior of pectin in the solvent-modifying additive system was studied in order to find conditions for the formation of high-viscosity gels suitable for soft dosage forms creation. The aminoglycoside antibiotic kanamycin and glycerin were used as modifying additives. Rheological measurements of pectin aqueous solutions were carried out on a Haake Mars III modular dynamic rheometer in the temperature range of 20-40 °C. To determine the ultimate shear stress, rheological measurements were carried out in the shear deformation mode at shear rates from 0.01 to 10 s -1 . In the course of rheological studies, it was shown that initial solutions of pectin, even at high concentrations, do not allow to achieve an optimal consistency corresponding to the soft dosage form. Systems with a yield point are formed in the presence of modifying additives. This is obviously due to the earlier formation of the network of entanglements in solutions due to the formation of a "bridge" bond between macromolecules. At the same time, the greater the polymer concentration and modifying additive in solutions, the greater the value of yield strength. Thus, the presence of modifying additives makes it possible to obtain systems based on pectin solutions suitable for use as the basis for soft dosage forms with rheological characteristics corresponding to the optimum consistency of hydrophilic ointments and gels under conditions that reflect their storage and direct use.