The oxirane derivative (2) was allowed to react with hydrazine hydrate, 4-aminobenzoic acid and o-phenylene diamine to give β-hydrazine alcohol derivative (3) and β-amino derivatives (4) and (5). The hydrazide (8) reacted with glucose, phthalic anhydride and aromatic aldehydes to give the phthalazine derivatives (9), (15) and (16a-c). A new heterocyclic molecules were synthesized using ethyl acetoacetate, acetyl acetone and benzoyl chloride with the hydrazide (8) to give the pyrazole derivatives (12), (14) and the oxadiazole derivative (18). The new compounds were synthesized with the objective of studying their antifungal and antimicrobial activity. Some of them gave positive results. The newly synthesized compounds were characterized on the basis of their spectral (1H-NMR, Mass spectrum, IR and Elementary analysis).

Arylidenmalonsäureester (I) reagieren mit Malodinitril (II) zu Gemischen aus Arylidenmalodinitrilen (III) und den Lactamen (IV).

Die Azlactone (I) werden mit Aminen (II), Hydrazinen (VI), Hydroxylamin (IX) und Natriumazid (X) unter den im Formelschema angegebenen Bedingungen zu den Verbindungen (III), (IV), (V), (VII), (VIII) bzw. (XI) umgesetzt.

Bei Kondensationen der Chalkone (II) mit Acetylaceton in Gegenwart von Na‐ethylat entstehen in Abhängigkeit von den Reaktionsbedingungen überwiegend entweder die Michael‐Addukte (I) oder Gemische von (III) und (IV).

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