⎯Major depressive disorder (MDD) is an important problem in psychophysical health and wellbeing of society in Russia and worldwide. In the present work, the role of apoptosis in the associative gene network of MDD was studied. The methods of prioritization were analyzed and candidate genes for further research were predicted. The quality of prioritization methods and their combinations was tested, and the most effective methods were selected. Prioritization was carried out for genes of the extrinsic apoptotic signaling pathway considering their role in the structure of the associative genetic network of MDD, since the external pathway of apoptosis is important for drug development. The methods of the ANDSystem, a computer system for reconstruction of gene networks on the basis of automatic data retrieval from scientific publications, were considered and used for gene prioritization. As a result of prioritization, some candidate genes were suggested for the further experimental study of their role in MDD pathogenesis, including CAV1, FYN, JAK2, PTEN, RAF1, RELA and SRC.

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Gastric cancer (GC) is one of the most common cancer types in the world with a high mortality rate. Hereditary predisposition for GC is not fully elucidated so far. The aim of this study was identification of possible new candidate genes, associated with the increased risk of gastric cancer development. Whole exome sequencing (WES) was performed on 18 DNA samples from adenocarcinoma specimens and non-tumor-bearing healthy stomach tissue from the same patient. Three pathogenic variants were identified: c.1320+1G>A in the CDH1 gene and c.27_28insCCCAGCCCCAGCTACCA (p.Ala9fs) of the VEGFA gene were found only in the tumor tissue, whereas c.G1874C (p.Cys625Ser) in the FANCA gene was found in both the tumor and normal tissue. These changes were found only in patients with diffuse gastric cancer and were absent in the DNA of healthy donors.

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